Huajiao Extract-Kaempferol 98%

Aug 11, 2021


Kaempferol is an organic substance with a chemical formula of C15H10O6. It belongs to flavonoids. The pure monomer is a yellow crystalline powder, slightly soluble in water, and soluble in organic solvents such as hot ethanol, ether and DMSO. It is mainly used for anticancer and inhibition Fertility, anti-epileptic, anti-inflammatory, antioxidant, antispasmodic, antiulcer, choleretic and diuretic, antitussive.


Basic Information:
[Chinese name]: Kaempferol
[Chemical name]: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
[Alias]: kaempferol-3 "kaempherol" Kaempherol; Robigenin; Pelargidenolon;
Rhamnolutein; Rhamnolutin; Populnetin; Trifolitin; Kempferol; Swartziol; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
[Molecular formula and molecular weight]: C15H10O6;  286.23
CAS number: 520-18-3
[Melting point and solubility]: 276°C-278°C, kaempferol is slightly soluble in water, soluble in hot ethanol, ether and alkali.
[Product introduction]: Kaempferol belongs to flavonols, yellow needle crystals.


Function:
◆ Anti-cancer and anti-cancer
Kaempferol is the most common flavonoid, and long-term diet can reduce the risk of cancer. Studies have reported that high intake of kaempferol can reduce the recurrence of advanced colorectal adenomas, and, compared with other daily dietary flavonoids, high intake of kaempferol can also significantly reduce the risk of pancreatic cancer. The latest research shows that kaempferol can also inhibit hepatocyte growth factor (HGF) and its receptor tyrosine protein kinase, which are related to the growth and metastasis of childhood medulloblastoma. Therefore, it can be prevented and treated by dietary kaempferol. Kind of disease.
Anti-infection and anti-inflammatory
◆ XU and other studies have shown that kaempferol has good antibacterial activity, and it also has an effect on methicillin-resistant Staphylococcus aureus (MRSA). The K-Br disk method shows that the concentration of 50 mg/tablet can make the zone of inhibition of MRSA. Up to 8.5mm, it also has good antibacterial activity against Vibrio cholerae and Enterococcus faecalis. In terms of antiviral, kaempferol can be inhibited lazily at a non-cytotoxic concentration.
In terms of anti-inflammatory, kaempferol mainly achieves anti-inflammatory effects by inhibiting the expression of inflammatory factors.
◆ Diabetes prevention
Atherosclerosis (AS) is a chronic inflammatory disease of the blood vessel wall. Studies have shown that kaempferol can not only inhibit copper ion-induced oxidation of low-density lipoprotein (LDL) to oxidized low-density lipoprotein (ox-LDL), It can also reduce the expression of CD 36 protein on the surface of THP-1 macrophages, prevent the cells from taking up ox-LDL, thereby preventing the occurrence of atherosclerosis.
Diabetes is an endocrine and metabolic disease that seriously threatens human health, and its incidence is increasing at an unprecedented rate. Studies have shown that kaempferol has the effect of acting as an agonist with the hypoglycemic drug rosiglitazone, but its adverse reactions are far weaker than rosiglitazone. It can increase the glucose of 3T3-L1 cells without affecting lipogenesis. Ingestion indicates that it is expected to become a new generation of insulin sensitizer.


Determination:High performance liquid chromatography
◆ 1. Chromatographic conditions
Chromatographic column: ODSC18 (4.6mmⅩ75mm)
Mobile phase: methanol-0.4% phosphoric acid-tetrahydrofuran (5:5:1) flow rate: 0.5mL/min
Wavelength: 365nm
◆2. Experimental steps
(1) Standard curve drawing
Take an appropriate amount of kaempferol reference substance (precisely weighed), and use methanol to make 0.004mg/mL and 0.005mg/mL solutions, respectively, as the reference solution. The quercetin and kaempferol reference substances were precisely drawn 4, 8, 12, 16, 20/true L each, and the chromatographic peak area was determined. Draw a standard curve with the content of kaempferol as the abscissa and the integral value of the peak area as the ordinate.


(2) Determination
Precisely draw 10uL each of the quercetin and kaempferol reference solution and the test solution, and inject them into a high performance liquid chromatograph to determine the peak area.

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