Do you know why mulberry leaf extract has the effect of lowering blood sugar?

Apr 27, 2021

Mulberry leaf, as a raw material for medicine and food, has long been widely used in the folks. In recent years, researchers from various countries have conducted systematic studies on the composition, function and mechanism of mulberry leaves. The results have found that mulberry leaves are rich in amino acids, cellulose, vitamins, minerals and a variety of physiologically active substances, which can reduce blood sugar, A variety of health care effects such as lowering blood pressure, lowering blood fat, and delaying aging.

Research data at home and abroad confirmed that alkaloids and polysaccharides are the main blood sugar lowering active ingredients in mulberry leaves.

So far, the research on the mechanism of mulberry leaf for lowering blood sugar has been carried out from two aspects: on the one hand, the research on the inhibitory effect of mulberry leaf components on the activity of disaccharide decomposing enzymes, and on the other hand, the mulberry leaf components promote insulin secretion from pancreatic β cells Start with.

Studies have shown that the hypoglycemic effect of mulberry leaves is achieved in two ways: 1. The mulberry leaf alkaloid (DN) inhibits the activity of disaccharide decomposing enzymes, thereby inhibiting the absorption of disaccharides in the small intestine and reducing post-eating blood sugar. High peak; 2. Mulberry leaf alkaloid fagomine and mulberry leaf polysaccharide promote β-cell secretion of insulin, and insulin can promote the cell's sugar utilization, liver glycogen synthesis and glucose metabolism, and ultimately achieve the effect of lowering blood sugar.

So far, there are 130 million people with diabetes worldwide, and the number is still increasing sharply. Its causes are mainly due to overeating, European and American eating habits, insufficient exercise, obesity and stress response. Diabetes patients do not have any symptoms at the beginning, but the frightening thing is that if they are ignored when it is difficult to detect, it will cause kidney damage, retinopathy, nerve damage, diabetic complications, or directly life-threatening myocardial infarction, cerebral thrombosis, etc. In order to avoid this situation, it is necessary to improve eating habits and strengthen prevention. In this regard, mulberry leaves as a natural non-toxic medicinal and edible resource have attracted more and more attention.

At present, although mulberry leaf extract enters the market with the content specification of the active ingredient DN, many manufacturers do not have the detection method for the active ingredient DN, so there is no corresponding production process, and the quality of the product is on the market. It is also uneven. Studies have shown that mulberry leaf products can have the same effect as the hypoglycemic drug Migretu on the market. The active ingredient content of mulberry leaf extract (DN) reported on the market is 2%. The content can only be reached after some refining processes, and its market price is also around 1,000 yuan/kg. However, there are few products with mulberry leaf polysaccharides and mulberry leaf flavonoids as specifications. Modern studies have shown that these by-products also have the effect of lowering blood sugar.


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