Mar 12, 2021
According to an experiment from the UIC/NIH Plant Dietary Supplement Research Center at the University of Illinois at Chicago, it was found that the enriched hop extract can activate a chemical pathway in the cell and help prevent breast cancer. Natural plant dietary supplements, such as hops, are becoming more and more popular among women experiencing postmenopausal symptoms. Because they are considered to be a safer alternative to hormone therapy, which is associated with an increased risk of breast cancer. The risk of breast cancer increases with a safer alternative. However, the potency and potential toxicity of the extract are still under investigation. The study was led by Professor Judy Bolton, a leader in medicinal chemistry and pharmacognosy from UIC School of Pharmacy, and applied hop extracts to two different breast cancer cell lines to see if they would affect estrogen metabolism. Estrogen metabolism is a key mechanism for the pathogenesis of breast cancer. A compound called 6-prenylnarigenin or 6-PN enhances the detoxification pathway in cells and is associated with a lower risk of breast cancer.
"We need to further explore this possibility, but our results show that 6-PN may have anti-cancer effects." Bolton said. In addition to 6-PN, Bolton and her colleagues studied the effects of 8-prenylnaringenin (8-PN), isoxanthohumol (IX) and xanthohumol (XH) on estrogen metabolism in breast cells. According to Bolton, 8-PN caused a slight increase in breast cell metabolism, while the other two compounds had no significant effect in either cell line. Breast cancer is one of the most commonly diagnosed cancers in women in the United States. About one-eighth. One American woman will get invasive breast cancer in her lifetime. According to the American Cancer Society, this year, there will be 246,660 new cases of invasive breast cancer and 61,000 new cases of non-invasive breast cancer in the United States.
The incidence of breast cancer has been declining since 2000, and has been rising for the 20 years before 2000. Between 2002 and 2003 alone, its incidence dropped by 7%. The results of the Women’s Health Initiative show that there is an association between HRT and increased breast cancer risk, so some people believe that part of the decline in incidence is due to the decrease in the use of hormone replacement therapy, or HRT. Bolton said that estrogen has been associated with an increased risk of breast cancer after menopause, especially since the 2002 report. The new research results were published in the journal "Chemical Research in Toxicology".
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