Difference Between Kojic Acid And Kojic Dipalmitate?

Mar 08, 2022

The raw materials of whitening cosmetics are constantly innovating, and people are constantly looking for high-efficiency, safe and cost-effective raw materials. As a relatively new whitening raw material, kojic acid dipalmitate has become a new favorite in the whitening market.

kojic acid dipalmitate for skin

Because of good stability, good whitening effect and no irritation to the skin. Kojic acid is also compounded because of its poor stability. Difficulty, gradually fade out of the market. This article analyzes the difference between Kojic Acid and Kojic Dipalmitate, hoping to provide some references for actual production.

Kojic Acid vs. Kojic Acid Dipalmitate Properties

Nane

Kojic Acid

Kojic Acid Dipalmitate

CAS

501-30-4

79725-98-7

Molecular Formula

C6H6O4

C38H66O6

Molecular Structure

Kojic AcidKojic Acid Dipalmitate

Difference in Effects

1. Stability

Kojic acid is unstable, sensitive to light and heat, and easily oxidized in the air. It reacts with many metal ions, especially with ferric ions, so that the formulated skin whitening product will gradually turn yellow-brown when placed and used.

Kojic acid dipalmitate has stability to light, heat and metal ions, good skin absorption, no irritation, etc. Because the active hydroxyl groups in the molecular structure of kojic acid are protected by the formation of esters, the stability is greatly improved. Therefore, the formulation difficulty is reduced. It can be easily melted into the oil phase and then emulsified, making it easy to formulate.

2. Whitening

Difference Between Kojic Acid And Kojic Dipalmitate

In the above chart:

The Y-axis is the absorption capacity of 475nm light wave, and the tyrosinase activity is fed back by measuring the color of various melanin intermediates. The x-axis is the elapsed time, calculated from the addition of tyrosinase to the medium.

The results show that:

The tyrosinase activity of the experimental group added with kojic acid was restored at 5 minutes, while the tyrosinase activity was only shown at 12 minutes in the kojic acid dipalmitate experimental group.

In clinical trials of pigmented patients, the effective rates of kojic acid and kojic acid dipalmitate were 60%-95% and 80%, respectively.

It can be seen that the whitening effect of kojic acid dipalmitate is better. In addition, its good fat solubility is more easily absorbed and utilized by the skin.

Summary

The following table is a comparison table of Kojic Acid And Kojic Acid Dipalmitate, hoping to provide reference for selecting and preparing raw materials for cosmetic finished products.

Name

Function

Mechanism

Recipe Difficulty

Stability

Irritant

Effectiveness

Safety

Price

Kojic acid

Whitening and bacteriostatic

tyrosinase inhibitor

++

++++

+

++++

++++

++

Kojic Dipalmitate

Whitening and moisturizing

tyrosinase inhibitor

+++++

+++++

+++++

+++++

+++

Note:

1.+++++: highest value

2.-: negative value



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